Coleonol or Forskolin is a chemical found in the roots of Coleus forskohlii, an Indian Coleus plant. It was first studied in 1974 by scientists from Central Drug Research Institute of India and Hoechst India in screening systems that analyzed medicative plants largely for cardiovascular activity. Aside from being used to increase cyclic AMP (cAMP) levels in study and research of cell philosophy, Forskolin has been used since ancient times to treat high blood pressure, heart disorders and angina and occasionally respiratory disorders like asthma. Coming back to cell research, Coleonol activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP thereby re sensitizing cell receptors.
A signal carrier is needed for better responsiveness between cells to hormones and also other extracellular signals. cAMP is the sign carrier. Hormones’ feedback control and cell communication in hypothalamus/pituitary gland axis is possible because of cAMP as it activates protein kinase A. In the area of healthcare, Forskolin, when taken by mouth can be used to treat allergies and other skin conditions like psoriasis and eczema. For a deeper understanding of forskolin creme, we suggest you check out this page. Other medical conditions treated are irritable bowel syndrome, obesity, menstrual problems, bladder infections, urinary tract infections, blood clots, insomnia, convulsions, sexual problems in men, and also advanced cases of cancer. Forskolin can additionally be employed intravenously during heart failure. Forskolin powder is said to be quite effective for asthma.
Glaucoma has been treated with Forskolin drops. Infusions from Coleus forskohlii are used by herbal product manufacturers also and being promoted to spread awareness about its use though conclusive, reliable scientific information upholding the medical benefits of Forskolin (when taken by mouth) aren’t now accessible. A lot of research is currently being undertaken worldwide. Forskolin produces powerful heartbeat and widens blood vessels thereby lowering blood pressure. It works on the heart muscles and walls of blood vessels. It acts as a vasodilator. One can find the drug over the counter in liquid form or as pills. Dosages vary based on the medical condition. Most commonly employed dosages are – 125mg coleus forskohlii herbal extract offering 12.5mg of Forskolin and 50mg coleus forskohlii herbal infusion offering 9mg of Forskolin. Research is limited to the dosages for different conditions.
0.2%-0.3% is generally the Forskolin content in coleus root. Therefore, it can be viewed the Forskolin content in crude coleus products may not be adequate for treating advanced medical conditions as they might not create the desired pharmacological effect. Concentrated Forskolin as found in standardized products are best to use where various infusion potencies of Coleus forskohlii like the 10% Forskolin, 18% Forskolin and 20% Forskolin are available. We found this page covering forskolin active more thoroughly. Yet, all the potencies haven’t yet been tested; thus it is impossible to say which potency is best to use.